| 2021-09-04 14:30:00September 4, 2021 | Maidenhead RFC 1XV vs North Walsham RFC | 21 - 24 | London & South East Premier | Maidenhead RFC |
| 2021-09-11 14:30:00September 11, 2021 | Wimbledon RFC 1XV vs Maidenhead RFC 1XV | 29 - 7 | London & South East Premier | Wimbledon RFC |
| 2021-09-18 14:30:00September 18, 2021 | Maidenhead RFC 1XV vs Dorking RFC 1 XV | 20 - 43 | London & South East Premier | Maidenhead RFC |
| 2021-09-25 14:30:00September 25, 2021 | Tring RFC 1XV vs Maidenhead RFC 1XV | 27 - 18 | London & South East Premier | Tring RFC |
| 2021-10-02 14:30:00October 2, 2021 | Maidenhead RFC 1XV vs Tunbridge Wells RFC 1XV | 16 - 10 | London & South East Premier | Maidenhead RFC |
| 2021-10-16 14:30:00October 16, 2021 | Maidenhead RFC 1XV vs Hertford RFC 1 XV | 29 - 48 | London & South East Premier | Maidenhead RFC |
| 2021-10-23 15:00:00October 23, 2021 | Westcombe Park RFC 1XV vs Maidenhead RFC 1XV | 45 - 13 | London & South East Premier | Westcombe Park RFC |
| 2021-10-30 14:30:00October 30, 2021 | Maidenhead RFC 1XV vs CS Stags RFC 1 XV | 54 - 12 | London & South East Premier | Maidenhead RFC |
| 2021-11-06 15:00:00November 6, 2021 | Havant RFC 1XV vs Maidenhead RFC 1XV | 26 - 12 | London & South East Premier | Havant RFC |
| 2021-11-13 14:30:00November 13, 2021 | Maidenhead RFC 1XV vs Sidcup RFC 1 XV | 20 - 24 | London & South East Premier | Maidenhead RFC |
| 2021-11-27 15:00:00November 27, 2021 | Brighton Blues RFC 1XV vs Maidenhead RFC 1XV | 25 - 16 | London & South East Premier | Brighton Blues RFC |
| 2021-12-04 14:00:00December 4, 2021 | Maidenhead RFC 1XV vs Sutton & Epsom RFC 1 XV | 24 - 20 | London & South East Premier | Maidenhead RFC |
| 2021-12-11 14:00:00December 11, 2021 | Sevenoaks RFC 1XV vs Maidenhead RFC 1XV | 43 - 0 | London & South East Premier | Sevenoaks RFC |
| 2022-01-08 14:00:00January 8, 2022 | Dorking RFC 1XV vs Maidenhead RFC 1XV | 42 - 0 | London & South East Premier | Dorking RFC |
| 2022-01-15 14:00:00January 15, 2022 | Maidenhead RFC 1XV vs Tring RFC 1XV | 29 - 27 | London & South East Premier | Maidenhead RFC |
| 2022-01-22 14:00:00January 22, 2022 | Tunbridge Wells RFC 1XV vs Maidenhead RFC 1XV | 14 - 45 | London & South East Premier | Tunbridge Wells RFC |
| 2022-01-29 15:00:00January 29, 2022 | Hertford RFC 1XV vs Maidenhead RFC 1XV | 44 - 5 | London & South East Premier | Hertford RFC |
| 2022-02-05 14:00:00February 5, 2022 | Maidenhead RFC 1XV vs Wimbledon RFC 1 XV | 15 - 32 | London & South East Premier | Maidenhead RFC |
| 2022-02-12 14:00:00February 12, 2022 | Maidenhead RFC 1XV vs Westcombe Park RFC 1XV | 38 - 27 | London & South East Premier | Maidenhead RFC |
| 2022-02-19 14:30:00February 19, 2022 | CS Stags 1863 RFC 1 XV vs Maidenhead RFC 1XV | 5 - 54 | London & South East Premier | CS Stags 1863 RFC |
| 2022-03-05 14:00:00March 5, 2022 | Maidenhead RFC 1XV vs Havant RFC 1 XV | 27 - 29 | London & South East Premier | Maidenhead RFC |
| 2022-03-12 15:00:00March 12, 2022 | Sidcup RFC 1XV vs Maidenhead RFC 1XV | 13 - 38 | London & South East Premier | Sidcup RFC |
| 2022-03-26 15:00:00March 26, 2022 | Maidenhead RFC 1XV vs Brighton Blues RFC 1 XV | 39 - 12 | London & South East Premier | Maidenhead RFC |
| 2022-04-02 15:00:00April 2, 2022 | Sutton & Epsom RFC 1XV vs Maidenhead RFC 1XV | 14 - 36 | London & South East Premier | Sutton & Epsom RFC |
| 2022-04-09 14:30:00April 9, 2022 | Maidenhead RFC 1XV vs Sevenoaks RFC 1 XV | 15 - 22 | London & South East Premier | Maidenhead RFC |
| 2022-04-23 15:00:00April 23, 2022 | North Walsham RFC 1XV vs Maidenhead RFC 1XV | 15:00:003:00 pm | London & South East Premier | North Walsham RFC |
